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| Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs); inhibits transpeptidation of peptidoglycan |
| - Streptococcal infections
- Pharyngitis
- Otitis media
- Scarlet fever
- Rheumatic fever
- Pneumococcal infections
- Pneumococcal pneumonia
- Meningitis
- Meningococcal infection
- Syphilis (T. pallidum)
| - Respiratory tract infections
- Urinary tract infections
- Skin and soft tissue infections
- Surgical prophylaxis
- Typhoid fever
- Penicillinase producing Staphylococcal infection
- Alternative to Penicillin G
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| - Local irritancy
- Pain at i.m. injection site
- Nausea on oral ingestion
- Thrombophlebitis
- Neurotoxicity
- Mental confusion
- Muscular twitchings
- Convulsions
- Coma
- Bleeding at high dose
- Hypersensitivity reactions
- rash
- Pruritis
- Urticaria
- Fever
- Allergy
- Diarrhea
| - Hypersensitivity (cross-reactivity with penicillins possible)
- Diarrhea
- Nephrotoxicity (rare)
|
| Drug of choice for syphilis and rheumatic fever | Has multiple generations with increasing gram-negative coverage |