1. Anatomy
  2. Physiology
  3. Pathology
  4. 1. Liver cell cancer
  5. Pharmacology
  6. Microbiology
  7. 2. Salmonella
    3. Shigella
    4. Escherichia coli
    5. Klebsiella
    6. Proteus
    7. Vibrio cholerae
    8. Clostridia
    9. Hepatitis
    10. Rota
    11. Adeno
    12. Norwalk
    13. Entamoeba histolytica
    14. Giardia lamblia
    15. Coccidian parasites and Cryptosporidium species
    16. Taenia species
    17. Echinococcus granulosus
    18. Heminolepis nana
    19. Ascaris lumbricoides
    20. Ancylostoma duodenale and Necator americanus
    21. Enterobius vermicularis
    22. Trichuris trichuria
  8. Biochemistry
  9. 23. Biochemical principles of Nutrition
Biochemistry
23. Biochemical principles of Nutrition
BASAL_METABOLIC_RATE
introduction
BMR=
  1. Working of heart
  2. Conduction of nerve impulse
  3. Reabsorption of renal tubules
  4. Gastrointestinal motility
  5. Na+ - K+ pump (50% BMR)
definition
Basal metabolic rate is the minimum amount of energy required by the body to maintain life at complete physical and mental rest in the post absorptive state.
basal_energy
BMR
factors_affecting_BMR
age
  1. > in children due to Lean Body Mass
  2. ⬇ by 2%/decade
sex
Men > women by 5% due to Lean Body mass
fever
⬆ by more than 10% /1 degree celcius
hormones
  1. Thyroid hormones have stimulatory effect on the metabolism of body
  2. BMR is elevated by about 70% in hyperthyroidism and lowered by about 40% in hypothyroidism thus used to assess thyroid function
  3. Other hormones like epinephrine, cortisol, growth hormones adn sex hormones ⬆ BMR
starvation
⬇ upto 50%
environment
⬆ in cold climate
surface_area
BMR ∝ Surface area ∝ Weight and Height
disease_state
decreases_in
  1. Adrenal insufficiency
increases_in
  1. infections
  2. leukemia
  3. polycythemia
  4. cardiac failure
  5. hypertension
physical_activity
⬆ with regular exercise due to ⬆ in surface area
racial_variations
Higher in Eskimos and less in Oriental women of USA than American women.
energy_expenditure_related_to_BMR
  1. Total energy expenditure (Fed state) = Basal energy + energy for physical activity + energy for synthesizing reserves
  2. sedentary_activities=1.1 - 1.2 x BMR
  3. vigorous_exercise=6-8 x BMR
CARBOHYDRATE_DIGESTION
process_of_digestion
digestion_in_mouth
Amylase
dietary_carbohydrates
disaccharides
  1. Sucrose (Cane sugar)
  2. Lactose (Milk sugar)
monosaccharide
hexose
  1. fructose
pentose
  1. ribose
polysaccharides
  1. Starch
  2. Glycogen
SPECIFIC_DYNAMIC_ACTION
fat_SDA
  1. storage
  2. mobilization
  3. oxidation
SDA_value
fat
13%
protein
30%
mixed_diet
10%
carbohydrate
5%
definition
The phenomenon of extra heat production by the body, over and above the calculated caloric value, when a given food is metabolized by the body is known as specific dynamic action
protein_SDA
  1. Deamination
  2. Synthesis of urea
  3. Biosynthesis of proteins
  4. Synthesis of triacylglycerol
significance
  1. SDA inversely proportional to quality of food
  2. So, protein is bad source of energy and fat is good source
  3. However, excessive utilization of fat leads to ketosis.
carbohydrate_SDA
  1. Conversion of glucose to glycogen
utilization_of_SDA_energy
  1. Digestion
  2. Absorption
  3. Transport
  4. Metabolism
  5. Storage
significance_of_high_protein_SDA
Make us feel warm and comfortable in cold weather.