❖ Stages: ◉ 1st Cleavage: - Meridional, holoblastic, and equal.
- Furrow appears at animal pole forming two blastomeres (right and left).
◉ 2nd Cleavage: - Holoblastic and equal.
- Forms 4 cells; grey crescent present only in two dorsal blastomeres.
◉ 3rd Cleavage: - Holoblastic and unequal.
- Plane is horizontal, above equator (latitudinal).
■ Blastomeres: ● Upper four: - Smaller (micromeres)
- Pigmented
- No yolk
● Lower four: - Larger (macromeres)
- Non-pigmented
- Yolk-laden
◉ 4th Cleavage: Two synchronous meridional divisions; forms 16 blastomeres.
◉ 5th Cleavage: Two simultaneous latitudinal divisions; forms 32 blastomeres.
◉ 6th Cleavage: Divisions become irregular and asynchronous; micromeres divide faster than macromeres.
◉ 7th Cleavage: Embryo appears as a morula (mulberry-shaped ball of cells).
◉ Morula: Solid ball of cells.
◉ Blastula: - Cavity (blastocoel) appears toward animal hemisphere; frog blastula is Coeloblastula.
- Blastocoel contains albuminous fluid secreted by surrounding cells.